Cinanserin

Cinanserin

Cinanserin is a serotonin antagonist that was first synthesized in the 1960s. It is classified as a psychoactive drug due to its ability to alter brain function, resulting in changes in perception, mood, consciousness, cognition, or behavior.

History

Cinanserin was first synthesized in the 1960s by the pharmaceutical company Hoffmann-La Roche. It was initially developed as a potential treatment for schizophrenia, but its clinical use has been limited due to its side effects and the development of more effective drugs.

Pharmacology

Cinanserin acts as a serotonin antagonist, meaning it blocks the action of serotonin, a neurotransmitter that is involved in the regulation of mood, appetite, and sleep. It is thought to work by blocking the 5-HT2A receptor, one of the receptor types for serotonin in the brain. This action can lead to a reduction in the symptoms of schizophrenia, such as hallucinations and delusions.

Clinical Use

The clinical use of Cinanserin has been limited due to its side effects, which can include dizziness, dry mouth, and constipation. It is also less effective than newer antipsychotic drugs. However, it has been used in some cases to treat insomnia and anxiety disorders.

Research

Research into the potential uses of Cinanserin is ongoing. Some studies have suggested that it may have potential as a treatment for Parkinson's disease, due to its ability to block the action of serotonin. Other research has focused on its potential use in the treatment of depression and obsessive-compulsive disorder.

See Also

• Serotonin antagonist
• Psychoactive drug
• Schizophrenia
• 5-HT2A receptor