Circumscribed disseminated keratosis Jadassohn Lew type
=Circumscribed Disseminated Keratosis Jadassohn-Lew Type =
Circumscribed disseminated keratosis Jadassohn-Lew type is a rare dermatological condition characterized by the presence of multiple keratotic papules and plaques on the skin. This condition is named after the dermatologists who first described it, Josef Jadassohn and Hermann Lew.
Clinical Presentation[edit | edit source]
Patients with circumscribed disseminated keratosis Jadassohn-Lew type typically present with keratotic papules that are well-circumscribed and distributed over various parts of the body. These lesions are often asymptomatic but can sometimes cause mild itching or discomfort.
Lesion Characteristics[edit | edit source]
The lesions are usually:
- Color: Skin-colored to brownish.
- Texture: Rough and scaly.
- Size: Varies from a few millimeters to several centimeters in diameter.
Pathophysiology[edit | edit source]
The exact pathophysiological mechanism of circumscribed disseminated keratosis Jadassohn-Lew type is not well understood. It is believed to involve abnormal keratinization processes within the epidermis. Keratinization is the process by which keratin, a protective protein, is produced in the skin.
Diagnosis[edit | edit source]
Diagnosis is primarily clinical, based on the appearance of the lesions. A skin biopsy may be performed to confirm the diagnosis and rule out other conditions such as seborrheic keratosis or actinic keratosis.
Differential Diagnosis[edit | edit source]
Conditions that may resemble circumscribed disseminated keratosis Jadassohn-Lew type include:
Treatment[edit | edit source]
There is no specific treatment for circumscribed disseminated keratosis Jadassohn-Lew type. Management is usually symptomatic and may include:
- Emollients: To soften the keratotic lesions.
- Keratolytic agents: Such as salicylic acid to reduce scaling.
- Topical retinoids: To promote normal keratinization.
Prognosis[edit | edit source]
The prognosis for patients with circumscribed disseminated keratosis Jadassohn-Lew type is generally good. The condition is benign and does not typically lead to complications. However, the lesions may persist or slowly increase in number over time.
Epidemiology[edit | edit source]
Circumscribed disseminated keratosis Jadassohn-Lew type is extremely rare, with only a few cases reported in the medical literature. It can affect individuals of any age but is most commonly seen in adults.
History[edit | edit source]
The condition was first described by Josef Jadassohn and Hermann Lew in the early 20th century. Their work laid the foundation for understanding various keratotic disorders of the skin.
See Also[edit | edit source]
NIH genetic and rare disease info[edit source]
Circumscribed disseminated keratosis Jadassohn Lew type is a rare disease.
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Contributors: Prab R. Tumpati, MD
