Club cell

Club cell

File:Club cells.jpg

Club cells in the bronchiole epithelium

A Club cell (also known as a Clara cell) is a type of cell in the bronchioles of the lungs. These cells are dome-shaped and have short microvilli, which are small projections on the surface of a cell that increase the cell's surface area. Club cells are found in the ciliated simple epithelium.

Function

Club cells serve several important functions in the lung. They secrete a variety of substances, including the Club cell secretory protein (CCSP), which helps to maintain the extracellular lining fluid of the airways. This protein has anti-inflammatory and immunomodulatory effects. Club cells also contribute to the defense of the lungs by detoxifying harmful substances inhaled into the lungs.

Clinical significance

Damage to Club cells can lead to a variety of lung diseases, including COPD and asthma. In addition, Club cell secretory protein has been used as a biomarker to detect lung damage, particularly in the context of occupational exposure to lung toxins.

See also

• Pulmonary alveolus
• Respiratory system
• Bronchiole

References

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