Club cell
Club cell
A Club cell (also known as a Clara cell) is a type of cell in the bronchioles of the lungs. These cells are dome-shaped and have short microvilli, which are small projections on the surface of a cell that increase the cell's surface area. Club cells are found in the ciliated simple epithelium.
Function[edit | edit source]
Club cells serve several important functions in the lung. They secrete a variety of substances, including the Club cell secretory protein (CCSP), which helps to maintain the extracellular lining fluid of the airways. This protein has anti-inflammatory and immunomodulatory effects. Club cells also contribute to the defense of the lungs by detoxifying harmful substances inhaled into the lungs.
Clinical significance[edit | edit source]
Damage to Club cells can lead to a variety of lung diseases, including COPD and asthma. In addition, Club cell secretory protein has been used as a biomarker to detect lung damage, particularly in the context of occupational exposure to lung toxins.
See also[edit | edit source]
References[edit | edit source]
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