Coibamide

Coibamide is a natural product isolated from a marine cyanobacterium collected off the coast of Panama. It is a cyclic depsipeptide with potent cytotoxicity against cancer cells, particularly those exhibiting multidrug resistance.

Structure and Synthesis

Coibamide A is a cyclic depsipeptide, meaning it is a peptide with a cyclic structure and contains a depside bond. The structure of coibamide A includes several unusual amino acids, including N-methyl amino acids and a rare thiazoline ring.

The total synthesis of coibamide A has been achieved by several research groups. The synthetic strategies typically involve solid-phase peptide synthesis (SPPS) to construct the linear peptide chain, followed by macrocyclization to form the cyclic structure.

Biological Activity

Coibamide A exhibits potent cytotoxicity against a variety of cancer cell lines. It is particularly effective against multidrug-resistant cancer cells, which are often resistant to other forms of chemotherapy. The mechanism of action of coibamide A is not fully understood, but it is thought to involve disruption of the cell cycle and induction of apoptosis.

See Also

• Cyanobacteria
• Natural product
• Cyclic depsipeptide
• Cancer
• Multidrug resistance

Coibamide Resources
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