Colforsin daropate

Colforsin daropate is a drug used in the treatment of cardiovascular diseases. It is a water-soluble derivative of forskolin, a diterpene derived from the roots of the Coleus forskohlii plant.

Pharmacology

Colforsin daropate acts as a direct adenylyl cyclase activator, bypassing the need for G protein activation. This results in an increase in cyclic AMP levels, leading to relaxation of smooth muscle in the heart and blood vessels, and a decrease in platelet aggregation.

Clinical Use

Colforsin daropate is used in the treatment of acute decompensated heart failure, and has been shown to improve hemodynamics in patients with severe heart failure. It is also used in the treatment of hypertension, due to its vasodilatory effects.

Side Effects

The most common side effects of colforsin daropate include hypotension, tachycardia, and arrhythmia. Less common side effects include nausea, vomiting, and headache.

Contraindications

Colforsin daropate is contraindicated in patients with hypersensitivity to the drug, and in patients with severe renal impairment. It should be used with caution in patients with peptic ulcer disease, due to the potential for increased gastric acid secretion.

See Also

• Forskolin
• Adenylyl cyclase
• Heart failure
• Hypertension