Collectin-10

Collectin-10, also known as CL-10 or mannose-binding lectin (MBL), is a protein that plays a crucial role in the innate immune system. It is part of the collectin family of proteins, which are characterized by their collagen-like sequences and lectin domains that can bind to specific sugar molecules. Collectin-10 is involved in the first line of defense against pathogens, facilitating the recognition and clearance of bacteria, viruses, and other foreign particles.

Structure and Function

Collectin-10 is a soluble protein that circulates in the blood plasma. It is composed of a collagen-like domain and a carbohydrate recognition domain (CRD). The CRD enables Collectin-10 to bind to specific carbohydrate patterns found on the surface of many pathogens. This binding is an essential step in the activation of the lectin pathway of the complement system, a critical component of the innate immune response.

Upon binding to pathogens, Collectin-10 can directly neutralize them or opsonize them, enhancing their phagocytosis by immune cells. Additionally, Collectin-10 can initiate the lectin pathway of complement activation, leading to the recruitment of inflammatory cells, opsonization of pathogens, and direct killing of pathogens through the formation of the membrane attack complex.

Genetics

The gene encoding Collectin-10 is located on chromosome 10 in humans. Variations in this gene have been associated with susceptibility to certain infections and autoimmune diseases, highlighting the importance of Collectin-10 in immune regulation and defense mechanisms.

Clinical Significance

Alterations in the levels or functional activity of Collectin-10 have been implicated in a variety of diseases. Low levels of Collectin-10 are associated with increased susceptibility to infections, particularly in neonates and immunocompromised individuals. Conversely, excessive activation of the lectin pathway, potentially due to high levels of Collectin-10, has been linked to autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).

Research is ongoing to explore the therapeutic potential of targeting Collectin-10 in diseases associated with immune dysregulation. Modulating the activity of Collectin-10 could provide a novel approach to enhancing host defense against infections or dampening excessive immune responses in autoimmune diseases.

See Also

• Innate immune system
• Complement system
• Lectin pathway
• Opsonization
• Autoimmune diseases

References

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