Crotylbarbital

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Crotylbarbital is a barbiturate derivative that was first synthesized in 1923. It is a sedative and hypnotic drug that was used in the treatment of insomnia and as a preoperative medication to induce sedation and amnesia before surgery. However, it has largely been replaced by newer drugs with fewer side effects and lower risk of dependence.

History[edit | edit source]

Crotylbarbital was first synthesized in 1923 by the German pharmaceutical company Bayer. It was marketed under the brand name Luminal and was widely used in the treatment of insomnia and as a preoperative medication.

Pharmacology[edit | edit source]

Crotylbarbital is a barbiturate, a class of drugs that act as central nervous system depressants. It works by increasing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits brain activity. This results in a decrease in brain activity and produces a calming effect.

Medical uses[edit | edit source]

Crotylbarbital was used as a sedative and hypnotic drug. It was used in the treatment of insomnia and as a preoperative medication to induce sedation and amnesia before surgery. However, it has largely been replaced by newer drugs with fewer side effects and lower risk of dependence.

Side effects[edit | edit source]

The side effects of crotylbarbital include drowsiness, dizziness, and confusion. Long-term use can lead to physical and psychological dependence. Overdose can cause respiratory depression, coma, and death.

See also[edit | edit source]

Crotylbarbital Resources
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Contributors: Prab R. Tumpati, MD