Cyclandelate

Cyclandelate is a vasodilator and calcium channel blocker that is primarily used in the treatment of vascular diseases. It works by relaxing and widening blood vessels, which improves blood flow and reduces the workload on the heart.

Mechanism of Action

Cyclandelate functions as a calcium antagonist, inhibiting the influx of calcium ions into vascular smooth muscle cells. This results in the relaxation of these cells and dilation of the blood vessels. The exact mechanism of action is not fully understood, but it is believed to involve the inhibition of calcium channels on the cell membrane.

Uses

Cyclandelate is used in the treatment of several vascular diseases, including peripheral artery disease, Raynaud's disease, and cerebrovascular disease. It can also be used to treat claudication, a condition characterized by leg pain caused by inadequate blood flow.

Side Effects

Like all medications, cyclandelate can cause side effects. Common side effects include headache, dizziness, nausea, and flushing. In rare cases, it can cause serious side effects such as arrhythmia, hypotension, and allergic reactions.

Contraindications

Cyclandelate should not be used in patients with known hypersensitivity to the drug. It should also be used with caution in patients with severe cardiac disease, as it can exacerbate symptoms.

Interactions

Cyclandelate can interact with other medications, including other vasodilators and calcium channel blockers. It can also interact with antihypertensive drugs, potentially leading to dangerously low blood pressure.

Dosage

The dosage of cyclandelate varies depending on the condition being treated and the patient's response to the medication. It is typically taken orally, in tablet form.

See Also

• Vasodilator
• Calcium channel blocker
• Vascular disease

References

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