Cyclic nucleotide-gated channel alpha 4

Cyclic nucleotide-gated channel alpha 4 (CNGA4) is a protein that in humans is encoded by the CNGA4 gene. This protein is a subunit of a cyclic nucleotide-gated ion channel that plays a crucial role in the sensory transduction pathways of olfactory neurons.

Structure

The CNGA4 protein is a member of the cyclic nucleotide-gated cation channel family. It is composed of six transmembrane domains, a pore-forming region, and a cyclic nucleotide-binding domain. The protein forms a heterotetrameric channel with other subunits, which is activated by the binding of cyclic AMP or cyclic GMP.

Function

CNGA4 is an essential component of the cyclic nucleotide-gated channels in olfactory neurons. These channels are responsible for converting odorant-induced changes in cyclic nucleotide concentrations into an electrical signal, which is then transmitted to the brain. The CNGA4 subunit modulates the function of these channels, affecting the sensitivity and adaptation of the olfactory response.

Clinical significance

Mutations in the CNGA4 gene have been associated with congenital anosmia, a condition characterized by the inability to perceive odors. Further research is needed to fully understand the role of CNGA4 in olfactory function and disease.

See also

• Cyclic nucleotide-gated ion channel
• Olfactory system
• Congenital anosmia

External links

• NCBI Gene
• UniProt