DAXX

DAXX (Death-domain associated protein) is a protein that in humans is encoded by the DAXX gene. DAXX is a multifunctional protein that interacts with various other proteins and has a role in several cellular processes, including apoptosis and gene expression.

Function

DAXX is a multifunctional protein that resides in multiple locations in the cell, including the nucleus and the cytoplasm. It interacts with a wide range of proteins, including p53, ATRX, and E2F1, and is involved in numerous cellular processes.

In the nucleus, DAXX acts as a histone chaperone, depositing histone H3.3 onto specific regions of the chromatin. This is important for the regulation of gene expression. DAXX also interacts with the transcription factor ATRX, which is involved in the maintenance of telomeres and heterochromatin formation.

In the cytoplasm, DAXX has a role in apoptosis, or programmed cell death. It interacts with the Fas death receptor and ASK1, and can activate the JNK pathway, leading to apoptosis.

Clinical significance

Mutations in the DAXX gene have been associated with several types of cancer, including pancreatic neuroendocrine tumors and pediatric glioblastoma. In these cancers, mutations in DAXX often occur alongside mutations in ATRX, and are associated with alternative lengthening of telomeres, a mechanism of telomere maintenance.

See also

• Apoptosis
• Histone chaperone
• Telomere

External links

• DAXX at the National Center for Biotechnology Information

DAXX Resources
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