Death-associated protein 6

Death-associated protein 6 (also known as DAXX) is a protein that in humans is encoded by the DAXX gene. DAXX is a multifunctional protein that resides in multiple subcellular compartments and it binds to many other proteins and genetic elements, implicating it in several biological processes and pathways.

Function

DAXX is a chromatin-associated protein that acts as a potent growth suppressor. It modulates apoptosis via its interactions with other proteins, including E3 ubiquitin-protein ligase MDM2, p53 and glucocorticoid receptor. DAXX also functions as a transcription regulator, working with many other regulatory proteins.

Structure

The DAXX protein has several domains that mediate its interactions with other proteins. These include a paired amphipathic helix (PAH) domain, a nuclear localization signal (NLS), and a SUMO-interaction motif (SIM).

Clinical significance

Alterations in the DAXX gene have been associated with several types of cancer, including pancreatic neuroendocrine tumors and pediatric glioblastoma.

See also

• Apoptosis
• Chromatin
• Transcription (genetics)