DCDC2

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Protein_DCDC2_PDB_2dnf

DCDC2

DCDC2 is a gene that encodes a protein involved in brain development and function. It plays a crucial role in neuronal migration and axon guidance during embryonic development. Mutations in the DCDC2 gene have been associated with various neurodevelopmental disorders, including dyslexia and autism spectrum disorders.

Function[edit | edit source]

The DCDC2 protein is primarily expressed in the brain and is involved in regulating the migration of neurons during brain development. It also plays a role in guiding the growth of axons, which are long projections that allow neurons to communicate with each other.

Clinical Significance[edit | edit source]

Mutations in the DCDC2 gene have been linked to dyslexia, a common learning disorder characterized by difficulties with reading and spelling. Studies have shown that variations in the DCDC2 gene may affect the structure and function of the brain regions involved in language processing.

Additionally, alterations in the DCDC2 gene have also been implicated in autism spectrum disorders, which are a group of neurodevelopmental conditions that affect social interaction, communication, and behavior. Research suggests that disruptions in the DCDC2 gene may contribute to the atypical brain development observed in individuals with autism.

Research[edit | edit source]

Scientists continue to investigate the role of the DCDC2 gene in brain development and its implications for neurodevelopmental disorders. Understanding how variations in this gene impact neuronal migration and axon guidance may provide valuable insights into the underlying mechanisms of conditions such as dyslexia and autism.

See also[edit | edit source]


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Contributors: Prab R. Tumpati, MD