DDR1
DDR1[edit | edit source]
DDR1, also known as Discoidin Domain Receptor Tyrosine Kinase 1, is a type of protein encoded by the DDR1 gene in humans. It is a member of a novel subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostelium discoideum protein discoidin I in their extracellular region. The DDR1 protein is a receptor for collagen and plays a crucial role in various biological processes.
Structure[edit | edit source]
The DDR1 protein is a transmembrane receptor that is activated by collagen binding. It consists of a large extracellular region, a single transmembrane region, and a cytoplasmic region. The extracellular region contains a discoidin domain, which is responsible for binding to collagen. The cytoplasmic region contains a tyrosine kinase domain, which is responsible for the protein's enzymatic activity.
Function[edit | edit source]
DDR1 is involved in various cellular functions, including cell adhesion, cell migration, proliferation, and differentiation. It plays a crucial role in tissue repair, primarily through its involvement in the regulation of cell-matrix interactions. In addition, DDR1 has been implicated in the pathogenesis of several diseases, including cancer, fibrosis, and atherosclerosis.
Clinical significance[edit | edit source]
Alterations in the DDR1 gene have been associated with several types of cancer, including breast cancer, lung cancer, and brain cancer. Overexpression of DDR1 has been observed in many cancer types, suggesting that it may play a role in tumor progression. In addition, DDR1 has been implicated in the development of fibrosis, a condition characterized by excessive deposition of collagen in tissues.
Research[edit | edit source]
Research on DDR1 has focused on understanding its role in disease and developing targeted therapies. Several small molecule inhibitors of DDR1 have been developed and are currently being tested in preclinical studies. These inhibitors have the potential to be used as targeted therapies for diseases associated with DDR1 overexpression or mutation.
See also[edit | edit source]
References[edit | edit source]
 | This protein-related article is a stub. You can help WikiMD by expanding it. |
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
