DGAT1

DGAT1 (Diacylglycerol O-acyltransferase 1) is an enzyme that in humans is encoded by the DGAT1 gene. This enzyme plays a crucial role in the synthesis of triglycerides by catalyzing the final step of the process.

Function

DGAT1 is part of the acyltransferase family of enzymes that convert diacylglycerol (DAG) and fatty acyl CoA into triglycerides. This process is essential for the storage of fatty acids and the production of lipoproteins that transport lipids in the blood.

Clinical significance

Mutations in the DGAT1 gene have been associated with several medical conditions. For instance, congenital diarrheal disorders can occur due to DGAT1 deficiency, which is caused by mutations in the DGAT1 gene. This condition is characterized by severe diarrhea and failure to thrive in infancy.

In addition, DGAT1 has been implicated in obesity and other metabolic diseases. Inhibitors of DGAT1 are being explored as potential treatments for these conditions.

See also

• DGAT2
• Acyltransferase
• Triglyceride

External links

• DGAT1 at the US National Library of Medicine Medical Subject Headings (MeSH)