DMPX

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DMPX

DMPX (3,7-dimethyl-1-propargylxanthine) is a xanthine derivative that acts as a potent and selective adenosine receptor antagonist. It is primarily used in scientific research to study the physiological and pharmacological roles of adenosine receptors.

Chemical Structure and Properties

DMPX is a methylated xanthine compound with the chemical formula C10H10N4O2. The structure of DMPX includes a xanthine core with methyl groups at the 3 and 7 positions and a propargyl group at the 1 position. This specific arrangement contributes to its high affinity and selectivity for adenosine receptors.

Mechanism of Action

DMPX functions by competitively inhibiting the binding of adenosine to its receptors. Adenosine is a neurotransmitter that plays a crucial role in various physiological processes, including sleep, cardiovascular function, and immune response. By blocking adenosine receptors, DMPX can modulate these processes, making it a valuable tool in pharmacological research.

Applications in Research

DMPX is widely used in neuroscience and pharmacology to investigate the role of adenosine receptors in different biological systems. It helps in understanding the effects of adenosine on central nervous system activities, such as sleep regulation, pain perception, and neuroprotection. Additionally, DMPX is used in cardiovascular research to study the impact of adenosine on heart rate and blood pressure.

Pharmacokinetics

The pharmacokinetics of DMPX, including its absorption, distribution, metabolism, and excretion, are critical for its effectiveness as a research tool. DMPX is known for its rapid absorption and ability to cross the blood-brain barrier, making it effective in central nervous system studies.

Safety and Handling

As with many research chemicals, proper safety protocols should be followed when handling DMPX. It should be used in a controlled laboratory environment, and appropriate personal protective equipment (PPE) should be worn to avoid exposure.

Related Compounds

DMPX is part of a broader class of xanthine derivatives, which include well-known compounds such as caffeine and theophylline. These compounds share a similar core structure but differ in their specific functional groups, leading to variations in their pharmacological effects.

See Also

• Adenosine receptor
• Xanthine
• Caffeine
• Theophylline
• Neurotransmitter
• Pharmacology