DUSP7

DUSP7 or Dual Specificity Phosphatase 7 is a protein that in humans is encoded by the DUSP7 gene. This protein is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.

Function

DUSP7 is known to regulate the activity of MAP kinases. It is involved in the inactivation of MAP kinases by dephosphorylation of both phosphotyrosine and phosphothreonine residues. This protein phosphatase is known to play a critical role in the regulation of cellular processes such as cell proliferation, cell differentiation, and apoptosis.

Clinical Significance

Alterations in the function of DUSP7 have been associated with several diseases, including cancer, diabetes, and neurodegenerative diseases. In cancer, overexpression of DUSP7 has been observed in several types of tumors, suggesting a potential role in tumor progression. In diabetes, DUSP7 has been implicated in the regulation of insulin signaling, and alterations in its function may contribute to insulin resistance. In neurodegenerative diseases, DUSP7 may play a role in neuronal survival and function.

See Also

• Dual specificity phosphatase
• Mitogen-activated protein kinase
• Protein phosphatase

References

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