Danofloxacin

Danofloxacin is a fluoroquinolone antibiotic used in veterinary medicine to treat infections caused by susceptible bacteria. It is particularly effective against Gram-negative bacteria, including Escherichia coli and Pasteurella multocida, and is commonly used in the treatment of respiratory tract infections in cattle and swine.

History

Danofloxacin was first approved for use in the United States in 1995. It was developed by Zoetis, a global animal health company, as part of their commitment to developing innovative solutions for animal health.

Mechanism of Action

Danofloxacin works by inhibiting the DNA gyrase and topoisomerase IV enzymes, which are essential for bacterial DNA replication, transcription, repair, and recombination. This inhibition results in the death of the bacteria.

Usage

Danofloxacin is administered orally or by injection. The dosage and duration of treatment depend on the type and severity of the infection, as well as the animal's weight and overall health status. It is important to follow the veterinarian's instructions carefully to ensure the effectiveness of the treatment and to prevent the development of antibiotic resistance.

Side Effects

As with all antibiotics, danofloxacin can cause side effects. These may include loss of appetite, vomiting, diarrhea, and changes in behavior. In rare cases, it can cause serious side effects such as seizures, severe allergic reactions, and damage to the cartilage in growing animals.

Resistance

The misuse and overuse of antibiotics like danofloxacin can lead to the development of antibiotic resistance, a serious global health concern. It is therefore crucial to use this medication responsibly, under the guidance of a veterinarian.

See Also

• Fluoroquinolone
• Veterinary medicine
• Antibiotic resistance