Dapivirine

Dapivirine (also known as TMC120 or DAPY) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to prevent HIV infection. It is specifically used in the form of a vaginal ring that is inserted once a month.

Mechanism of Action

Dapivirine works by inhibiting the action of reverse transcriptase, an enzyme that HIV uses to replicate its genetic material. By blocking this enzyme, Dapivirine prevents the virus from multiplying and spreading to other cells.

Clinical Trials

Clinical trials have shown that Dapivirine is effective in reducing the risk of HIV infection in women. The ASPIRE study and The Ring Study both found that the Dapivirine ring reduced the risk of HIV infection by approximately 30%.

Side Effects

Common side effects of Dapivirine include vaginal discomfort and discharge. In rare cases, it can cause allergic reactions.

Approval

Dapivirine was approved for medical use in the European Union in July 2020. It is also approved in the United States.

See Also

• Non-nucleoside reverse transcriptase inhibitor
• HIV/AIDS
• Clinical trial

Dapivirine Resources
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