Topical gels

Topical Gels

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Diagram of a colloid gel structure.

A topical gel is a type of semisolid formulation that is applied to the skin or mucous membranes. These gels are used for delivering active ingredients directly to the site of action or for systemic absorption. They are composed of a three-dimensional network of polymer chains that are capable of retaining a significant amount of water or other solvents.

Composition

Topical gels typically consist of a gelling agent, a solvent, and an active ingredient. Common gelling agents include carbomer, xanthan gum, and guar gum.

Guar gum is a common gelling agent derived from the guar bean.

The solvent is usually water or alcohol, which helps in the dissolution of the active ingredient and provides a cooling effect upon application. The active ingredient can vary widely depending on the intended use of the gel, ranging from analgesics and anti-inflammatory agents to antibiotics and antifungals.

Types of Topical Gels

Hydrogel

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A hydrogel dressing used for wound care.

A hydrogel is a type of gel that contains a high percentage of water. Hydrogels are often used in wound care and burn treatment due to their ability to provide a moist environment that promotes healing.

Alcohol-Based Gels

Alcohol-based gels are commonly used for antiseptic purposes, such as hand sanitizers. These gels evaporate quickly, leaving the skin feeling refreshed and clean.

Oil-Based Gels

Oil-based gels are used for their emollient properties, providing a barrier that helps to retain moisture in the skin. They are often used in cosmetic and dermatological applications.

Applications

Topical gels are used in a variety of applications, including:

• Pain relief: Gels containing menthol or capsaicin are used for relieving muscle and joint pain.
• Allergy treatment: Gels with diphenhydramine are used to relieve itching and irritation from allergic reactions.

Benadryl Itch Stopping Gel is used for relieving itching.

• Acne treatment: Gels containing benzoyl peroxide or salicylic acid are used to treat acne.
• Moisturization: Gels with hyaluronic acid are used to hydrate and plump the skin.

Mechanism of Action

Topical gels work by delivering the active ingredient directly to the site of action. The gel matrix allows for controlled release of the active ingredient, providing sustained effects over time. The viscosity of the gel can be adjusted to control the rate of release and absorption.

Advantages and Disadvantages

Advantages

• Easy to apply and spread over large areas.
• Non-greasy and quickly absorbed by the skin.
• Can provide localized treatment with minimal systemic side effects.

Disadvantages

• May cause skin irritation or allergic reactions in sensitive individuals.
• Some gels may leave a sticky residue on the skin.

Related Pages

• Ointment
• Cream (pharmaceutical)
• Lotion
• Transdermal patch

References

• Topical_gels
• 

  Colloid gel

• Hydrogel wound dressing

• 

  Skin

• Cluster bean (guar)

• Sorbitol

• SKLEER Natural Skin Restoration Gel

• 

  Benadryl Itch Stopping Gel

• Salting In - Salting Out