Decoquinate

Decoquinate

Decoquinate is an antiprotozoal agent that is primarily used in the prevention and treatment of coccidiosis, a parasitic disease affecting a variety of animals, particularly poultry and livestock. It is a quinolone derivative and is marketed under various brand names, including Deccox.

History

Decoquinate was first synthesized in the 1960s as part of a series of compounds designed to combat malaria. However, it was found to be particularly effective against Eimeria, a genus of apicomplexan parasites that cause coccidiosis.

Mechanism of Action

Decoquinate works by inhibiting the electron transport chain in the mitochondria of the parasite. This disrupts the parasite's ability to produce adenosine triphosphate (ATP), which is essential for its survival and reproduction.

Use in Veterinary Medicine

In veterinary medicine, decoquinate is used as a feed additive to prevent coccidiosis in poultry and livestock. It is particularly effective in preventing the disease in young animals, which are more susceptible to infection.

Safety and Side Effects

Decoquinate is generally considered safe for use in animals. However, it can cause some side effects, including reduced feed intake and weight gain. In rare cases, it can cause neurological symptoms, such as tremors and incoordination.

Regulatory Status

In the United States, decoquinate is regulated by the Food and Drug Administration (FDA) and is approved for use in poultry and livestock. In the European Union, it is approved by the European Medicines Agency (EMA).

See Also

• Antiprotozoal agent
• Coccidiosis
• Quinolone
• Veterinary medicine