Deoxycholic acid

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Deoxycholic acid is a secondary bile acid, a metabolic byproduct of intestinal bacteria. It is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. Deoxycholic acid is produced in the liver from cholic acid and is involved in the emulsification of fats for absorption in the intestine.

Biochemistry

Deoxycholic acid is synthesized in the liver from cholic acid by the action of intestinal bacteria. It is then conjugated with either glycine or taurine to form glycodeoxycholic acid or taurodeoxycholic acid, respectively. These conjugated forms are secreted into the bile and stored in the gallbladder. Upon ingestion of food, bile is released into the small intestine where deoxycholic acid aids in the digestion and absorption of dietary fats.

Function

Deoxycholic acid plays a crucial role in the digestion and absorption of fats and fat-soluble vitamins in the small intestine. It acts as a detergent, breaking down large fat globules into smaller micelles that can be more easily absorbed by the intestinal lining. This process is essential for the efficient absorption of dietary lipids.

Medical Uses

Deoxycholic acid is used in medical treatments, particularly in the non-surgical treatment of submental fat, commonly known as a double chin. It is an active ingredient in injectable formulations that help to break down and absorb fat cells in the treated area. This treatment is known as lipolysis.

Side Effects

The use of deoxycholic acid in medical treatments can have side effects, including swelling, bruising, pain, numbness, redness, and areas of hardness in the treatment area. More serious side effects can include trouble swallowing and nerve injury in the jaw that can cause an uneven smile or facial muscle weakness.

Research

Ongoing research is exploring the potential uses of deoxycholic acid in other areas of medicine, including its role in the treatment of other localized fat deposits and its potential anti-inflammatory properties.

See Also

• Bile acid
• Cholic acid
• Lipolysis
• Gallbladder
• Intestinal bacteria