Des(1-3)IGF-1
Des(1-3)IGF-1 is a protein that is encoded by the IGF1 gene in humans. It is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults.
Function[edit | edit source]
Des(1-3)IGF-1 is a truncated version of Insulin-like growth factor 1 (IGF-1), with the first three amino acids at the N-terminus removed. This modification enhances the protein's ability to bind to the IGF-1 receptor, increasing its potency.
Des(1-3)IGF-1 is primarily produced in the liver as an endocrine hormone and plays a crucial role in muscle repair and growth by activating the Akt signaling pathway. This pathway stimulates muscle protein synthesis and inhibits protein degradation.
Clinical significance[edit | edit source]
Des(1-3)IGF-1 has been studied for its potential therapeutic applications in the treatment of various medical conditions, including growth hormone deficiency, muscle wasting, and neurodegenerative diseases.
However, the use of Des(1-3)IGF-1 is not without risks. It can lead to hypoglycemia due to its insulin-like effects. Long-term use can also potentially increase the risk of cancer, as IGF-1 is a potent cell growth and proliferation factor.
See also[edit | edit source]
References[edit | edit source]
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