Des(1-3)IGF-1

Des(1-3)IGF-1 is a protein that is encoded by the IGF1 gene in humans. It is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults.

Function

Des(1-3)IGF-1 is a truncated version of Insulin-like growth factor 1 (IGF-1), with the first three amino acids at the N-terminus removed. This modification enhances the protein's ability to bind to the IGF-1 receptor, increasing its potency.

Des(1-3)IGF-1 is primarily produced in the liver as an endocrine hormone and plays a crucial role in muscle repair and growth by activating the Akt signaling pathway. This pathway stimulates muscle protein synthesis and inhibits protein degradation.

Clinical significance

Des(1-3)IGF-1 has been studied for its potential therapeutic applications in the treatment of various medical conditions, including growth hormone deficiency, muscle wasting, and neurodegenerative diseases.

However, the use of Des(1-3)IGF-1 is not without risks. It can lead to hypoglycemia due to its insulin-like effects. Long-term use can also potentially increase the risk of cancer, as IGF-1 is a potent cell growth and proliferation factor.

See also

• Insulin-like growth factor 1
• Growth hormone
• Akt signaling pathway