Deuterated

Deuterated is a term used in chemistry to describe a compound in which one or more of the hydrogen atoms have been replaced with deuterium, an isotope of hydrogen. Deuterium is a stable isotope of hydrogen with a natural abundance in the oceans of Earth of approximately one atom in 6420 of hydrogen. Deuterium is frequently symbolized by the chemical symbol D.

Chemical Properties

Deuterated compounds have similar chemical properties to their non-deuterated counterparts. However, the replacement of hydrogen with deuterium can lead to subtle changes in how the compound behaves. This is due to the fact that deuterium is approximately twice as heavy as hydrogen, which can affect the speed at which chemical reactions occur. This phenomenon is known as the Kinetic isotope effect.

Applications

Deuterated compounds are used in a variety of scientific and industrial applications. In NMR spectroscopy, deuterated solvents are often used to avoid interference from the solvent in the spectrum. In Medicinal chemistry, deuterated drugs are being investigated as a way to increase the effectiveness and reduce the side effects of certain medications.

Deuterated Drugs

Deuterated drugs are a new class of drugs that are being developed for their potential to improve the safety and effectiveness of existing medications. The first deuterated drug, Deutetrabenazine, was approved by the FDA in 2017 for the treatment of Huntington's disease.

See Also

• Deuterium
• Isotopes of hydrogen
• Kinetic isotope effect
• Deuterated drug
• Deutetrabenazine

Deuterated Resources
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