Dexindoprofen

Dexindoprofen.svg

Dexindoprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used for its analgesic and anti-inflammatory properties. It is a derivative of indoprofen, and it is used in the management of mild to moderate pain and inflammation.

Pharmacology

Dexindoprofen works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for the formation of prostaglandins. Prostaglandins are compounds that mediate inflammation, pain, and fever. By reducing the production of prostaglandins, dexindoprofen alleviates symptoms associated with inflammation and pain.

Chemical Properties

Dexindoprofen is a chiral molecule, meaning it has two enantiomers. The active form is the (S)-enantiomer, which is responsible for its pharmacological effects. The chemical structure of dexindoprofen is similar to that of other NSAIDs, with a benzoyl group attached to a phenylpropionic acid backbone.

Clinical Use

Dexindoprofen is used in the treatment of various conditions that involve pain and inflammation, such as osteoarthritis, rheumatoid arthritis, and dysmenorrhea. It is also used for the relief of mild to moderate pain, such as headaches, dental pain, and musculoskeletal pain.

Side Effects

Like other NSAIDs, dexindoprofen can cause gastrointestinal side effects, such as gastric ulceration, bleeding, and dyspepsia. It may also increase the risk of cardiovascular events such as myocardial infarction and stroke, especially with long-term use. Patients with a history of asthma, allergic reactions, or renal impairment should use dexindoprofen with caution.

Contraindications

Dexindoprofen is contraindicated in patients with known hypersensitivity to the drug or other NSAIDs, active peptic ulcer disease, and severe heart failure. It should be used with caution in patients with hypertension, heart disease, and liver dysfunction.

Also see

• Non-steroidal anti-inflammatory drug
• Indoprofen
• Cyclooxygenase
• Prostaglandin
• Pain management