Non-steroidal anti-inflammatory drug

From WikiMD's Wellness Encyclopedia

Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drugs that provide analgesic (pain-killing) and antipyretic (fever-reducing) effects, and, in higher doses, anti-inflammatory effects.

Mechanism of action[edit | edit source]

NSAIDs work by inhibiting the activity of cyclooxygenase enzymes (COX-1 and/or COX-2). In cells, these enzymes are involved in the synthesis of key biological mediators, namely prostaglandins which are involved in inflammation, and thromboxanes which are involved in blood clotting.

Uses[edit | edit source]

NSAIDs are used to treat pain and inflammation caused by a variety of conditions such as arthritis, menstrual pain, headache, and influenza.

Side effects[edit | edit source]

Common side effects of NSAIDs include stomach upset, heartburn, and a rash. More severe side effects include kidney failure, liver failure, ulcers, heartburn, and a decreased ability to clot the blood.

See also[edit | edit source]

References[edit | edit source]


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Contributors: Prab R. Tumpati, MD