Non-steroidal anti-inflammatory drug

Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drugs that provide analgesic (pain-killing) and antipyretic (fever-reducing) effects, and, in higher doses, anti-inflammatory effects.

Mechanism of action

NSAIDs work by inhibiting the activity of cyclooxygenase enzymes (COX-1 and/or COX-2). In cells, these enzymes are involved in the synthesis of key biological mediators, namely prostaglandins which are involved in inflammation, and thromboxanes which are involved in blood clotting.

Uses

NSAIDs are used to treat pain and inflammation caused by a variety of conditions such as arthritis, menstrual pain, headache, and influenza.

Side effects

Common side effects of NSAIDs include stomach upset, heartburn, and a rash. More severe side effects include kidney failure, liver failure, ulcers, heartburn, and a decreased ability to clot the blood.

See also

• Analgesic
• Antipyretic
• Cyclooxygenase
• Prostaglandin
• Thromboxane

References

Non-steroidal anti-inflammatory drug Resources
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