Tolmetin
Information about Tolmetin[edit source]
Tolmetin is a nonsteroidal antiinflammatory drug (NSAID) that is available by prescription only and used for therapy of chronic arthritis.
Liver safety of Tolmetin[edit source]
Tolmetin is associated with low rates of serum aminotransferase elevations during therapy and has been linked to rare instances of clinically apparent drug induced liver injury.
Mechanism of action of Tolmetin[edit source]
Tolmetin (tol' met in) belongs to the acetic acid derivative class of NSAIDs similar to diclofenac, sulindac and indomethacin. Like other NSAIDs, tolmetin is a cyclo-oxygenase (Cox-1 and Cox-2) inhibitor which blocks the formation of prostaglandins that are important in pain and inflammatory pathways.
FDA approval information for Tolmetin[edit source]
Tolmetin has analgesic as well as antipyretic and antiinflammatory activities. Tolmetin is one of the oldest NSAIDs in clinical use having been approved in the United States in 1976. It is currently not commonly used, having been replaced by NSAIDs with longer half-lives and better tolerance. The current indications for tolmetin include osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and juvenile rheumatoid arthritis.
Dosage and administration for Tolmetin[edit source]
Tolmetin is available only by prescription and in several generic forms of 200, 400 and 600 mg tablets or capsules and formerly under the brand name Tolectin. The usual dose in adults is 1 to 2 g per day in divided doses.
Side effects of Tolmetin[edit source]
As with other NSAIDs, tolmetin is generally well tolerated, but side effects can include headache, dizziness, somnolence, gastrointestinal upset, nausea, abdominal discomfort, diarrhea, peripheral edema and hypersensitivity reactions.
Nonsteroidal Antiinflammatory Drugs (NSAIDs)
Acetaminophen, Celecoxib, Diclofenac, Diflunisal, Etodolac, Fenoprofen, Flurbiprofen, Ibuprofen, Indomethacin, Ketoprofen, Ketorolac, Mefenamic Acid, Meloxicam, Nabumetone, Naproxen, Nimesulide, Oxaprozin, Phenylbutazone, Piroxicam, Rofecoxib, Sulindac, Tolmetin
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