Dienestrol

Dienestrol

Dienestrol is a synthetic, non-steroidal estrogen that was first synthesized in 1939. It is used in medicine for its estrogenic effects, such as in the treatment of menopausal symptoms and in hormone replacement therapy.

History

Dienestrol was first synthesized in 1939, shortly after the discovery of the estrogenic properties of stilbestrol. It was introduced for medical use in the 1940s, around the same time as diethylstilbestrol (DES), and was marketed under a variety of brand names including Cycladiene, Dienoestrol, Dienoestrol Ortho, Sexadiene, and Follormon.

Medical uses

Dienestrol is used in medicine for its estrogenic effects. It is used in the treatment of menopausal symptoms, such as hot flashes and vaginal dryness. It is also used in hormone replacement therapy (HRT) for women who have undergone menopause. In addition, it has been used to treat prostate cancer and breast cancer, although it is not commonly used for these purposes today.

Pharmacology

Dienestrol is a synthetic, non-steroidal estrogen, which means it is not derived from natural sources and does not have a steroid structure. It is a type of phenolic compound, specifically a stilbene derivative. It works by binding to and activating the estrogen receptor, which is found in various tissues throughout the body.

Side effects

Like other estrogens, dienestrol can have a number of side effects. These can include nausea, vomiting, bloating, breast tenderness, headache, and changes in menstrual periods. More serious side effects can include blood clots, stroke, and an increased risk of certain types of cancer.

See also

• Estrogen
• Hormone replacement therapy
• Menopause
• Phenolic compound
• Stilbene derivative