Diethylstilbestrol dipropionate

Diethylstilbestrol dipropionate is a synthetic, nonsteroidal estrogen that was formerly used in the treatment of menopausal and postmenopausal disorders. It was also used formerly to treat certain types of breast and prostatic malignancies.

Pharmacology

Diethylstilbestrol dipropionate is a long-acting estrogen derivative. It is a prodrug of diethylstilbestrol (DES), which means it is metabolized in the body to produce DES. DES is a potent estrogen that binds to the estrogen receptors in various tissues, including the breast, uterus, and prostate, and stimulates their growth.

Uses

Diethylstilbestrol dipropionate was used in the past for the treatment of menopausal and postmenopausal disorders. It was also used in the treatment of certain types of breast and prostatic malignancies. However, it is no longer used due to its association with serious side effects, including an increased risk of endometrial cancer and cardiovascular disease.

Side Effects

The side effects of diethylstilbestrol dipropionate are similar to those of other estrogens. They include nausea, vomiting, bloating, breast tenderness, and an increased risk of blood clots. Long-term use of diethylstilbestrol dipropionate can also lead to an increased risk of endometrial cancer and cardiovascular disease.

History

Diethylstilbestrol dipropionate was first synthesized in the 1930s as a long-acting estrogen derivative. It was widely used in the mid-20th century for the treatment of menopausal and postmenopausal disorders, as well as certain types of breast and prostatic malignancies. However, its use declined in the 1970s after studies showed that it was associated with an increased risk of endometrial cancer and cardiovascular disease.

See Also

• Diethylstilbestrol
• Estrogen
• Menopause
• Postmenopause
• Breast cancer
• Prostate cancer
• Endometrial cancer
• Cardiovascular disease

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