Dihydroergolines

Dihydroergolines are a class of ergoline derivatives that are used clinically for their vasoconstrictive and dopamine antagonist properties. They are primarily used in the treatment of Parkinson's disease and other neurological disorders.

History[edit | edit source]

Dihydroergolines were first synthesized in the 1960s as a result of research into the ergot alkaloids. These compounds were found to have potent vasoconstrictive and dopamine antagonist properties, leading to their use in the treatment of various neurological disorders.

Pharmacology[edit | edit source]

Dihydroergolines act as agonists at various dopamine receptors, with a particular affinity for the D2 receptor. They also have vasoconstrictive properties, which can be useful in the treatment of conditions such as migraines.

Clinical use[edit | edit source]

Dihydroergolines are used in the treatment of Parkinson's disease, as they can help to alleviate the motor symptoms associated with this condition. They are also used in the treatment of other neurological disorders, such as restless legs syndrome and dystonia.

Side effects[edit | edit source]

Like all medications, dihydroergolines can cause side effects. These can include nausea, vomiting, dizziness, and hallucinations. In rare cases, they can also cause more serious side effects such as psychosis or heart problems.

See also[edit | edit source]

Dihydroergolines Resources
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