Dihydroethisterone

Dihydroethisterone (DHE), also known as 17α-ethyl-5α-dihydrotestosterone (17α-ethyl-DHT) or as androstanolone ethyl ether, is a steroid and androgen that is used in hormone replacement therapy (HRT). It is a derivative of testosterone and is considered a potent androgen.

History[edit | edit source]

Dihydroethisterone was first synthesized in the 1930s, making it one of the earliest synthetic androgens. It was developed as a potential treatment for hypogonadism and other conditions associated with low testosterone levels.

Pharmacology[edit | edit source]

Dihydroethisterone is a synthetic androgen, meaning it mimics the effects of testosterone in the body. It binds to and activates the androgen receptor, which regulates the expression of genes involved in male sexual development and maintenance.

Medical uses[edit | edit source]

Dihydroethisterone is used in hormone replacement therapy, particularly in men who have low testosterone levels. It can help to alleviate symptoms such as fatigue, depression, and decreased libido. It is also used in the treatment of certain types of prostate cancer.

Side effects[edit | edit source]

As with other androgens, dihydroethisterone can have side effects. These can include acne, hair loss, and an increased risk of prostate disease. It can also cause changes in mood and behavior.