Dihydrotestosterone (disambiguation)

Dihydrotestosterone (DHT) refers to a potent androgen hormone that plays a critical role in the development of male characteristics. It is derived from testosterone, the primary male sex hormone, through the action of the enzyme 5α-reductase. DHT is involved in various physiological processes, including the development of male genitalia during embryogenesis, the maturation of male secondary sexual characteristics during puberty, and the regulation of hair growth and prostate function in adults. Due to its significant impact on human health and development, DHT and its related topics encompass a broad range of scientific and medical fields.

Dihydrotestosterone (DHT) in Medicine and Biology

DHT's role in the body is multifaceted, influencing both normal physiological functions and contributing to the pathogenesis of certain conditions. In the context of medicine and biology, DHT is associated with:

• Androgenetic alopecia or male pattern baldness, where high levels of DHT contribute to the miniaturization of hair follicles.
• Benign prostatic hyperplasia (BPH), a condition characterized by the enlargement of the prostate gland, which can be influenced by DHT levels.
• Prostate cancer, where DHT is considered a factor in the development and progression of the disease.
• The development of male external genitalia during embryonic development.
• The role in the sexual differentiation process during embryogenesis.

Dihydrotestosterone (DHT) and its Derivatives

Beyond its natural form, synthetic derivatives of DHT have been developed for medical use, including:

• Anabolic steroids, which are synthetic substances similar to the male sex hormone testosterone. Some of these are structurally modified forms of DHT designed to enhance anabolic effects while minimizing androgenic effects.
• Medications like finasteride and dutasteride, which are 5α-reductase inhibitors used to treat conditions like androgenetic alopecia and BPH by reducing DHT levels.

Research and Clinical Implications

Research into DHT and its effects on the human body continues to be a significant area of interest, with implications for treating and understanding various health conditions. Studies on DHT contribute to the fields of endocrinology, dermatology, urology, and oncology, among others.

See Also

• Testosterone
• 5α-Reductase inhibitor
• Androgen receptor
• Sexual differentiation
• Anabolic steroid