Diiodotyrosine

Diiodotyrosine (DIT) is an amino acid that is used in the synthesis of thyroid hormones. It is produced from tyrosine by the action of the enzyme thyroid peroxidase.

Structure and properties

Diiodotyrosine is a tyrosine molecule with two iodine atoms attached. The iodine atoms are added to the tyrosine molecule by the enzyme thyroid peroxidase. This process is known as iodination.

Role in thyroid hormone synthesis

Diiodotyrosine is a key intermediate in the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of these hormones is regulated by the thyroid-stimulating hormone (TSH), which is produced by the pituitary gland.

Clinical significance

Abnormalities in the synthesis of diiodotyrosine can lead to disorders of thyroid hormone production, such as hypothyroidism or hyperthyroidism. In addition, certain drugs, such as propylthiouracil and methimazole, can inhibit the production of diiodotyrosine, leading to a decrease in thyroid hormone levels.

See also

• Thyroid hormone
• Thyroid peroxidase
• Iodination
• Thyroxine
• Triiodothyronine

Diiodotyrosine Resources
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