Dimethylbenzanthracene

Dimethylbenzanthracene (DMBA) is a potent carcinogen and mutagen commonly used in scientific research to induce tumors in experimental animals. It is a polycyclic aromatic hydrocarbon (PAH) that is structurally similar to the carcinogenic compound benzo(a)pyrene. DMBA is not naturally occurring and is synthesized for research purposes.

Chemical Structure and Properties

DMBA is a derivative of anthracene, a polycyclic aromatic hydrocarbon (PAH) consisting of three fused benzene rings. The compound is modified with two methyl groups, hence the name "dimethyl." The chemical formula of DMBA is C20H16. It is a solid at room temperature and is not soluble in water.

Use in Research

DMBA is primarily used in biomedical research as a tumor initiator. It is most commonly used to induce skin cancer in mice, but it can also induce tumors in the mammary glands, ovaries, and other organs. DMBA acts by causing DNA damage, which can lead to mutations if not repaired correctly by the cell. This DNA damage can trigger the development of cancer.

Health Effects

Exposure to DMBA can have serious health effects. As a potent carcinogen, it can cause cancer in humans. It is also a mutagen, meaning it can cause genetic mutations. Long-term exposure can lead to skin, lung, and bladder cancer. Short-term exposure can cause skin irritation and eye damage.

Safety and Handling

Due to its carcinogenic properties, DMBA should be handled with extreme care. It should be used only in a controlled laboratory setting, with appropriate safety measures in place. These include the use of personal protective equipment (PPE), such as gloves and lab coats, and proper ventilation.

See Also

• Carcinogen
• Mutagen
• Polycyclic aromatic hydrocarbon
• Benzo(a)pyrene