Dopamine beta-hydroxylase
Dopamine beta-hydroxylase (DBH), also known as dopamine beta-monooxygenase, is an enzyme that catalyzes the conversion of dopamine to norepinephrine.
Function[edit | edit source]
DBH is a copper-containing oxygenase that exists as a tetramer with four identical subunits. It is located in the synaptic vesicles of postganglionic sympathetic neurons and in adrenal medulla, where it converts dopamine to norepinephrine. This conversion is a critical step in the sympathetic nervous system's production of norepinephrine, which plays a key role in the body's fight or flight response.
Clinical significance[edit | edit source]
Mutations in the DBH gene can lead to Dopamine beta hydroxylase deficiency, a condition characterized by a lack of norepinephrine and epinephrine in patients. Symptoms can include orthostatic hypotension, ptosis, and nasal stuffiness.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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