Drosha

Drosha is a protein that in humans is encoded by the DROSHA gene. It is a class 2 ribonuclease III enzyme that plays a pivotal role in the processing of microRNA precursors.

Function

The DROSHA gene encodes a protein that is a member of the RNase III family. This protein is a component of the Microprocessor complex, which is involved in the biogenesis of microRNAs from the primary microRNA transcript. This protein is a nuclear RNA-specific ribonuclease (RNase) that processes small, regulatory RNAs.

Clinical significance

Mutations in the DROSHA gene have been associated with cancer, including Wilms' tumor, breast cancer, and lung cancer. The protein encoded by this gene is also thought to be involved in cellular differentiation and apoptosis.

Interactions

Drosha has been shown to interact with DGCR8.

See also

• MicroRNA
• DGCR8
• Ribonuclease III

External links

• Drosha at WikiMD

Drosha Resources
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