Dynein axonemal light chain 1

Dynein axonemal light chain 1 is a protein that in humans is encoded by the DNAL1 gene. This protein is a component of dynein, a motor protein complex responsible for the movement of cilia and flagella.

Function

Dynein axonemal light chain 1 is a part of the dynein complex in cells. Dynein is a motor protein that moves along microtubules in cells and is involved in many crucial cellular processes, including cell division, vesicle transport, and organelle movement. The DNAL1 gene provides instructions for making a protein that is a component of the dynein complex.

Structure

The DNAL1 gene is located on the short (p) arm of chromosome 14 at position 24.3. The protein encoded by this gene is a light chain protein, and it interacts with other dynein components to form the functional dynein complex.

Clinical significance

Mutations in the DNAL1 gene have been associated with primary ciliary dyskinesia, a disorder characterized by chronic respiratory tract infections, abnormally positioned internal organs, and infertility. This is due to the role of dynein in the movement of cilia and flagella, which are necessary for the normal functioning of many organs and tissues.

See also

• Dynein
• Primary ciliary dyskinesia
• Microtubule
• Chromosome 14