E2F3

E2F3 is a protein that in humans is encoded by the E2F3 gene. It is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of the cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses.

Function

The E2F3 protein is a transcriptional activator that binds to DNA sequences, specifically the E2 recognition site 5'-TTTC[CG]CGC-3'. It is involved in cell cycle regulation, DNA replication, and likely, apoptosis. E2F3 is also known to interact with retinoblastoma protein, which controls the progression through the G1 phase of the cell cycle.

Clinical Significance

Alterations in the E2F3 gene have been associated with various types of cancer, including lung cancer, bladder cancer, and prostate cancer. Overexpression of E2F3 has been observed in these cancers, suggesting a potential role in their development and progression.

See Also

• E2F
• Cell cycle
• Retinoblastoma protein

References

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External Links

• E2F3 at the US National Library of Medicine Medical Subject Headings (MeSH)

Further Reading

• "E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos."