EGR3
EGR3 (Early Growth Response 3) is a gene that encodes a protein in humans. It is a member of the EGR family of C2H2-type zinc finger proteins. It is involved in neuronal differentiation and in the regulation of cell growth and survival.
Function[edit | edit source]
EGR3 is a transcription factor that is activated by nerve growth factor (NGF). It is essential for the development and maintenance of the central nervous system (CNS). EGR3 regulates the expression of genes involved in synaptic plasticity, neuronal survival, and neuronal differentiation.
Clinical significance[edit | edit source]
Alterations in the EGR3 gene have been associated with schizophrenia, bipolar disorder, and major depressive disorder. Studies have shown that EGR3 expression is decreased in the prefrontal cortex of individuals with schizophrenia.
Research[edit | edit source]
Research on EGR3 has focused on its role in neurodevelopmental disorders, neurodegenerative diseases, and cancer. Studies have shown that EGR3 is involved in the regulation of cell proliferation, cell differentiation, and apoptosis.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
