ELAV-like protein 1
ELAV-like protein 1 (also known as HuR or Hu antigen R) is a protein that in humans is encoded by the ELAVL1 gene. It is a member of the ELAV family of RNA-binding proteins which contain three RNA recognition motifs (RRMs) and bind AU-rich elements (AREs) in mRNA.
Function[edit | edit source]
ELAV-like protein 1 is involved in the regulation of RNA stability and translation, playing a crucial role in post-transcriptional gene regulation. It binds to and stabilizes mRNAs such as those containing AREs found in the 3' untranslated regions of many proto-oncogenes and cytokine genes. The protein is also involved in the regulation of cell proliferation, cell differentiation, and cell death.
Clinical significance[edit | edit source]
Alterations in the function of ELAV-like protein 1 have been associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. In cancer, overexpression of the protein has been observed and is associated with increased tumor growth and progression. In neurodegenerative diseases, the protein is thought to play a role in the selective vulnerability of neurons.
Structure[edit | edit source]
The ELAVL1 gene is located on the short (p) arm of chromosome 19 at position 13.2. The protein encoded by this gene is approximately 36 kDa in size and contains three RRMs.
Research[edit | edit source]
Research into ELAV-like protein 1 is ongoing, with studies focusing on its role in disease progression and potential as a therapeutic target.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD