ERAP2

ERAP2 or Endoplasmic Reticulum Aminopeptidase 2 is a protein that in humans is encoded by the ERAP2 gene. It is a zinc metalloprotease of the M1 family and is involved in the final stages of the presentation of antigenic peptides to T cells.

Function

ERAP2 trims peptides to an optimal length for presentation by Major Histocompatibility Complex (MHC) class I molecules. It is involved in the processing of antigenic precursors and is critical for the correct functioning of the immune system.

Structure

The ERAP2 protein is a 960 amino acid long protein with a molecular weight of approximately 111 kDa. It is a homodimer and its structure is similar to that of other M1 family aminopeptidases.

Clinical significance

Alterations in the ERAP2 gene have been associated with several diseases, including ankylosing spondylitis, psoriasis, and birdshot chorioretinopathy. It has also been implicated in the susceptibility to infectious diseases such as tuberculosis and malaria.

Research

Research into ERAP2 is ongoing, with studies focusing on its role in the immune response and its potential as a target for immunotherapy.

See also

• ERAP1
• Antigen presentation
• Major Histocompatibility Complex (MHC)

References

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