ERVWE1

ERVWE1 is a human gene that encodes the glycoprotein (g) syncytin-1, which is involved in the formation of the syncytiotrophoblast, a tissue essential for placental development and function. The gene is part of the endogenous retrovirus group W envelope (ERVWE1) family.

Function

The ERVWE1 gene provides instructions for making a protein called syncytin-1. This protein is critical for the development and function of the placenta, which attaches the developing fetus to the uterine wall to allow nutrient uptake, waste elimination, and gas exchange via the mother's blood supply.

Syncytin-1 is involved in the formation of the syncytiotrophoblast, a specialized tissue that lines the placenta and interfaces with the mother's blood supply. The syncytiotrophoblast is formed by the fusion of cells called cytotrophoblasts, a process that is facilitated by syncytin-1.

Clinical significance

Mutations in the ERVWE1 gene can lead to placental dysfunction, which can result in complications during pregnancy, including preeclampsia, intrauterine growth restriction, and preterm birth.

See also

• Endogenous retrovirus
• Syncytin
• Placenta

References

ERVWE1 Resources
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