Endomorphin-2
Endomorphin-2 is a naturally occurring opioid peptide that has a high affinity and specificity for the mu opioid receptor. It is found in the nervous system of many animals, and is involved in a variety of physiological processes, including pain modulation and stress response.
Structure and Function[edit | edit source]
Endomorphin-2 is a tetrapeptide, meaning it is composed of four amino acids. Its sequence is Tyr-Pro-Phe-Phe, which is derived from the precursor protein proopiomelanocortin (POMC). The structure of endomorphin-2 allows it to bind to the mu opioid receptor with high affinity and specificity.
The binding of endomorphin-2 to the mu opioid receptor triggers a cascade of events within the cell, leading to the inhibition of pain signals. This makes endomorphin-2 a potent analgesic, or painkiller. In addition to its role in pain modulation, endomorphin-2 is also involved in the body's response to stress.
Clinical Significance[edit | edit source]
Due to its potent analgesic properties, endomorphin-2 has been the subject of much research in the field of pain management. It has been suggested that endomorphin-2 could be used as a novel non-addictive painkiller. However, more research is needed to fully understand the potential therapeutic applications of endomorphin-2.
See Also[edit | edit source]
References[edit | edit source]
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