Endomorphin-1

Endomorphin-1 is a naturally occurring opioid peptide that has a high affinity and selectivity for the mu opioid receptor. It is found in the central nervous system (CNS) and has been shown to have potent analgesic effects.

Structure and Function

Endomorphin-1 is a tetrapeptide, meaning it is composed of four amino acids. Its sequence is Tyr-Pro-Trp-Phe, and it is derived from the precursor protein proopiomelanocortin (POMC).

The function of endomorphin-1 is primarily related to pain modulation. It binds to the mu opioid receptor, which is widely distributed in the CNS, particularly in areas associated with pain perception such as the periaqueductal gray and the dorsal horn of the spinal cord. Activation of this receptor by endomorphin-1 leads to inhibition of pain signals, producing analgesia.

Clinical Significance

Due to its potent analgesic effects, endomorphin-1 has potential for use in pain management. However, like other opioids, it also has the potential for abuse and addiction. Research is ongoing to develop analogs of endomorphin-1 that retain its analgesic properties but have reduced potential for abuse.

See Also

• Endomorphin-2
• Opioid peptide
• Mu opioid receptor

References

Endomorphin-1 Resources
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