Eomesodermin

Eomesodermin (also known as Eomes) is a T-box transcription factor that plays a crucial role in the development and differentiation of various cell types during embryogenesis. It is encoded by the Eomes gene in humans.

Function[edit | edit source]

Eomesodermin is primarily involved in the formation of mesoderm and endoderm during early embryonic development. It is also essential for the differentiation of CD8+ T cells and natural killer cells, which are critical components of the immune system.

Structure[edit | edit source]

The Eomes gene is located on the long (q) arm of chromosome 3 at position 21.3. The protein encoded by this gene belongs to the T-box family of transcription factors, characterized by a DNA-binding domain known as the T-box.

Role in Disease[edit | edit source]

Mutations in the Eomes gene have been associated with various diseases. For example, a lack of Eomesodermin has been linked to congenital heart defects, neural tube defects, and immune system disorders.

Research[edit | edit source]

Research on Eomesodermin is ongoing, with studies focusing on its role in immune response, embryonic development, and disease pathogenesis. Understanding the function of Eomesodermin could lead to new treatments for a variety of diseases.