Epiestriol

Epiestriol is a steroid and an estrogen that is not currently marketed in any country. It is a metabolite of estradiol and estriol. Epiestriol has been found to possess relatively low estrogenic potency compared to other estrogens, which may have implications for its potential health risks.

Chemistry[edit | edit source]

Epiestriol, also known as 16-epiestriol, as well as estra-1,3,5(10)-triene-3,16α,17β-triol, is a naturally occurring estrane steroid and an estrogen. It is a metabolite of estradiol, and to a lesser extent of estrone, and is also a positional isomer of estriol (16β-epiestriol).

Pharmacology[edit | edit source]

Epiestriol is an estrogen, or an agonist of the estrogen receptors. It has approximately 30 times lower affinity for the estrogen receptors relative to estradiol. The estrogenic potency of epiestriol in terms of increase in uterine weight is also about 30 times lower than that of estradiol.

History[edit | edit source]

Epiestriol was first described in the literature in 1965. It was studied for potential medical use, but was never marketed.

See also[edit | edit source]

Epiestriol Resources
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