Epietiocholanolone

Epietiocholanolone is a steroid and metabolite of testosterone. It is a type of androgen and is produced in the liver. Epietiocholanolone is known to be involved in the immune system's response to stress and illness.

Structure and Synthesis

Epietiocholanolone is a 17-ketosteroid, meaning it has a ketone group at the 17th carbon position. It is synthesized from testosterone through a series of biochemical reactions involving the enzymes 5α-reductase and 3α-hydroxysteroid dehydrogenase.

Function

Epietiocholanolone has been found to have immunomodulatory effects. It can stimulate the immune system by increasing the activity of white blood cells, particularly neutrophils. This can lead to an increased response to infection or inflammation.

Clinical Significance

Elevated levels of epietiocholanolone have been associated with various medical conditions, including Cushing's syndrome, prostate cancer, and polycystic ovary syndrome. It can also be used as a biomarker to monitor the progression of these diseases.

See Also

• Androgen
• Testosterone
• Steroid
• Metabolite
• Immune system
• Stress (biology)