Epoprostenol sodium

Epoprostenol Sodium is a synthetic form of prostacyclin, a naturally occurring substance in the body that inhibits platelet aggregation and causes vasodilation. It is primarily used in the treatment of pulmonary arterial hypertension (PAH).

Pharmacology

Epoprostenol Sodium works by dilating the blood vessels in the lungs, reducing the workload on the heart and improving its efficiency. This helps to decrease symptoms such as shortness of breath and tiredness, and can improve exercise capacity.

Clinical Use

Epoprostenol Sodium is used to treat pulmonary arterial hypertension (PAH) and to prevent thrombosis in patients undergoing dialysis. It is also used off-label for the treatment of Raynaud's phenomenon and digital ulcers.

Side Effects

Common side effects of Epoprostenol Sodium include headache, nausea, vomiting, and diarrhea. More serious side effects can include hypotension, sepsis, and bleeding.

Dosage

The dosage of Epoprostenol Sodium is individualized for each patient based on their body weight and the severity of their condition. It is administered intravenously, usually through a permanent central venous catheter.

History

Epoprostenol Sodium was first approved by the Food and Drug Administration (FDA) in 1995 for the treatment of PAH. It is marketed under the brand name Flolan.

See Also

• Prostacyclin
• Pulmonary arterial hypertension
• Platelet aggregation
• Vasodilation