Equine estrogen

Equine estrogen is a type of estrogen that is derived from the urine of pregnant mares. It is a complex mixture of different types of estrogens, including estrone, equilin, and equilenin. Equine estrogens are used in hormone replacement therapy for women who are experiencing symptoms of menopause.

History

Equine estrogen was first isolated in the 1930s and has been used in hormone replacement therapy since the 1940s. It was initially marketed under the brand name Premarin, which is an abbreviation for "pregnant mares' urine".

Pharmacology

Equine estrogens are absorbed into the body and bind to estrogen receptors, where they mimic the effects of natural estrogens. They are metabolized in the liver and excreted in the urine and feces.

Uses

Equine estrogens are used in hormone replacement therapy to treat symptoms of menopause, such as hot flashes and vaginal dryness. They are also used to prevent osteoporosis in postmenopausal women.

Side effects

The use of equine estrogens has been associated with an increased risk of breast cancer, stroke, and deep vein thrombosis. Other side effects can include nausea, bloating, and irregular bleeding.

See also

• Estrogen
• Hormone replacement therapy
• Menopause
• Premarin