ErbB1
ErbB1 is a protein that in humans is encoded by the EGFR gene. It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB1), HER2/neu (ErbB2), Her 3 (ErbB3) and Her 4 (ErbB4). Mutations affecting EGFR expression or activity could result in cancer.
Function[edit | edit source]
EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.
Clinical significance[edit | edit source]
EGFR is a gene that codes for a protein called epidermal growth factor receptor. EGFR is found on the surface of some cells where it plays a role in the communication of cells and the growth of new cells. An excess of this protein has been associated with cancer growth.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- ErbB1 at WikiMD
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Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD