Erbumine

Erbumine is a chemical compound that is often used in the pharmaceutical industry. It is a salt form of the active ingredient enalapril, which is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used primarily for the treatment of hypertension and congestive heart failure.

Chemical Properties

Erbumine is the maleate salt of enalapril. The chemical formula for erbumine is C20H28N2O5.C4H4O4. It is a white to off-white crystalline powder that is soluble in water and ethanol.

Pharmacology

Erbumine works by inhibiting the angiotensin-converting enzyme (ACE), which is responsible for the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor that increases blood pressure by narrowing the blood vessels. By inhibiting this enzyme, erbumine helps to relax blood vessels, thereby lowering blood pressure and improving blood flow.

Medical Uses

Erbumine is primarily used in the treatment of:

• Hypertension: It helps to lower high blood pressure, reducing the risk of stroke, heart attack, and kidney problems.
• Congestive heart failure: It helps to improve the symptoms of heart failure by reducing the workload on the heart.
• Left ventricular dysfunction: It is used to improve survival and reduce the risk of hospitalization in patients with left ventricular dysfunction.

Side Effects

Common side effects of erbumine include:

• Cough
• Dizziness
• Fatigue
• Headache
• Nausea

Serious side effects may include:

• Angioedema
• Hyperkalemia
• Kidney dysfunction

Contraindications

Erbumine is contraindicated in patients with:

• History of angioedema
• Pregnancy
• Severe renal impairment

Related Pages

• Enalapril
• Angiotensin-converting enzyme inhibitor
• Hypertension
• Congestive heart failure
• Angiotensin II

{{Drugbox | verifiedrevid = 477002123 | IUPAC_name = (2S)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]propanoyl]pyrrolidine-2-carboxylic acid | image = Enalapril.svg | width = 200 | CAS_number = 75847-73-3 | ATC_prefix = C09 | ATC_suffix = AA02 | PubChem = 5388960 | DrugBank = DB00584 | ChemSpiderID = 10482048 | UNII = 69PN84IO1A | KEGG = D07854 | ChEBI = 47775 | ChEMBL = 637 | C=20 | H=28 | N=2 | O=5 | molecular_weight = 376.447 g/mol | bioavailability = 60% | protein_bound = 50-60% | metabolism = Hepatic | elimination_half-life = 11 hours | excretion = Renal }}